1.
Indian J Biochem Biophys
;
1984 Aug; 21(4): 241-7
Article
in English
| IMSEAR
| ID: sea-26467
2.
Indian J Biochem Biophys
;
1981 Dec; 18(6): 421-4
Article
in English
| IMSEAR
| ID: sea-26733
3.
Indian J Physiol Pharmacol
;
1980 Apr-Jun; 24(2): 77-83
Article
in English
| IMSEAR
| ID: sea-107403
ABSTRACT
Clonidine in a dose-range of 2.5 microgram to 80 microgram caused positive inotropic effect, which was accompanied by increase in the cyclic AMP levels and phosphorylase-activation of the isolated perfused guinea pig heart. Clonidine-induced biochemical and mechanical effects were blocked by burimamide, an H2-receptor antagonist Propranolol (1 x 10(-6)M), phentolamine (1 x 10(-6)M) or reserpine pretreatment, did not affect the clonidine responses on the perfused guinea pig heart. Clonidine reduced the 4-methyl-histamine (H2-agonist) responses of guinea pig heart. Our data suggest that the cardiac effects of clonidine may be due to stimulation of H2-type of receptors.
Subject(s)
Animals , Burimamide/pharmacology , Clonidine/antagonists & inhibitors , Cyclic AMP/analysis , Dose-Response Relationship, Drug , Female , Guinea Pigs , Male , Myocardial Contraction/drug effects , Myocardium/enzymology , Phosphorylase a/analysis , Phosphorylases/analysis , Receptors, Histamine H2/drug effects , Stimulation, Chemical , Thiourea/analogs & derivatives
4.
Indian J Exp Biol
;
1975 Sep; 13(5): 422-4
Article
in English
| IMSEAR
| ID: sea-59314